The Statistical Models Project (SMp) Normal Tissue Complication Probability (NTCP) Model and Parameters
نویسندگان
چکیده
منابع مشابه
A stochastic model for the normal tissue complication probability (NTCP) and applicationss.
The normal tissue complication probability (NTCP) is a measure for the estimated side effects of a given radiation treatment schedule. Here we use a stochastic logistic birth-death process to define an organ-specific and patient-specific NTCP. We emphasize an asymptotic simplification which relates the NTCP to the solution of a logistic differential equation. This framework is based on simple m...
متن کاملNormal tissue complication probability (NTCP) parameters for breast fibrosis: pooled results from two randomised trials.
INTRODUCTION The dose-volume effect of radiation therapy on breast tissue is poorly understood. We estimate NTCP parameters for breast fibrosis after external beam radiotherapy. MATERIALS AND METHODS We pooled individual patient data of 5856 patients from 2 trials including whole breast irradiation followed with or without a boost. A two-compartment dose volume histogram model was used with b...
متن کاملA Stochastic Model for the Normal Tissue Complication Probability (NTCP) in Radiation Treatment of Cancer
The normal tissue complication probability (NTCP) is a measure for the estimated side effects of a given radiation treatment schedule. Here we use a stochastic logistic birth death process to define an organ specific and patient specific NTCP. We emphasise an asymptotic simplification which relates the NTCP to the solution of a logistic differential equation. This framework allows for a direct ...
متن کاملUse of normal tissue complication probability models in the clinic.
The Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) review summarizes the currently available three-dimensional dose/volume/outcome data to update and refine the normal tissue dose/volume tolerance guidelines provided by the classic Emami et al. paper published in 1991. A "clinician's view" on using the QUANTEC information in a responsible manner is presented along with a...
متن کاملAnalytical approach to estimate normal tissue complication probability using best fit of normal tissue tolerance doses into the NTCP equation of the linear quadratic model.
AIMS AND OBJECTIVES Aims and objectives of this study are to get the best fit of the normal tissue tolerance doses to the NTCP model of the linear quadratic model. METHODS AND MATERIALS To compute the NTCP, the modified form of the Poisson cell kill model of NTCP, based on linear-quadratic model, is used. The model has been applied to compute the parameters of the NTCP model using clinical to...
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ژورنال
عنوان ژورنال: American Journal of Applied Mathematics and Statistics
سال: 2017
ISSN: 2328-7306
DOI: 10.12691/ajams-5-4-1